research September 18, 2026 via J Foot Ankle Surg

Evaluation of Closure Materials on Outcomes Following Transmetatarsal Amputation: A Retrospective Review.

This study examined how different methods of closing the surgical wound after a transmetatarsal amputation (removal of the front part of the foot) affect healing and the need for further surgery. Transmetatarsal amputation is often performed when a toe or part of the foot has severe infection or poor blood flow, especially in people with diabetes. Researchers reviewed medical records of patients who had this amputation at their institution over a period of time. They compared two main closure methods: healing by secondary intention (leaving the wound open to heal naturally) and primary closure (suturing the wound closed right away). They found that the closure method did not significantly affect the rate of wound healing or the need for additional surgery. However, they did find that patients with poor blood flow (peripheral arterial disease) had worse outcomes regardless of closure method. The study suggests that the choice of closure material may not be as important as ensuring good blood flow to the foot. This is a retrospective review, meaning it looks back at past cases, so it cannot prove cause and effect and may be limited by the information available in the records.

Medically reviewed by Professor Wang Cheng, MD

Key takeaways

  • Transmetatarsal amputation removes the front of the foot; how the wound is closed may affect healing.
  • Study compared leaving the wound open versus closing it immediately after surgery.
  • Closure method did not change healing rates or need for further amputation.
  • Poor blood flow was a stronger predictor of poor outcomes than closure technique.
  • Ask your doctor about the best closure method for your situation and how to improve circulation.
  • Good blood flow and proper wound care are crucial for successful amputation healing.

Editor's note

Think of your foot's blood supply like a network of rivers delivering vital nutrients. When a transmetatarsal amputation is needed, it's like removing a damaged section of a riverbank—the remaining tissue needs good blood flow to heal. This study shows that how you close the wound (like choosing whether to cover it with a bandage or leave it open) matters less than making sure those rivers are flowing well. For patients told their wound won't heal or amputation is the only option, this research suggests that focusing on improving circulation could be key—and that there may be more than one way to manage the surgical wound. At China's specialist DFU centres, transmetatarsal amputation is routinely performed, and doctors there often use advanced techniques to assess and improve blood flow before and after surgery. For an overseas patient, this means you can access comprehensive care that addresses both the amputation and the underlying circulation problems, potentially improving your chances of healing and preserving mobility.

This content summarizes published medical research for educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making treatment decisions.

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